Paleoclimate records in central China reveal asynchronous hydroclimate changes to those from both northern and southern China during the Holocene. Whether such a spatial mode works for the Younger Dryas event (YD), a prominent abrupt climate change during the transition from the last glacial to the Holocene, is poorly constrained by quantitative records. In this study, we apply the novel coupled hydrogen isotope composition of leaf wax n-alkanes and oxygen isotope of hemicellulose (δ²H_n-alkane-δ¹⁸O_sugar) paleohygrometer approach to reconstruct the paleo relative humidity (RH) on a peat layer spanning 13.1–10.0 cal ka BP in the Dajiuhu peatland, central China. The coupled δ²H_n-alkane-δ¹⁸O_sugar approach reveals that the RH was relatively low in the period of 12.7–12.1 cal ka BP (RH avg. 79%, 1σ 4.9%) and then turned to relatively high values during 12.1–11.7 cal ka BP (RH avg. 88.6%, 1σ 3.9%). A dry interval happened from the end of the YD to 11.3 cal ka BP (RH< 80%). A general wetting trend during the YD period in central China contrasts with the prevailing drying in northern China and maybe also in southern China. The occurrence of a wetting trend during the YD period in central China probably results from the interplay between the westerlies and the East Asian summer monsoon under a context with weak summer monsoon intensity.